http://apologeticspress.org/APContent.aspx?category=9&article=4670
A Book Review and Summary of John C. Sanford's Genetic Entropy and the Mystery of the Genome

Dr.
John Sanford is a plant geneticist and inventor who conducted research
at Cornell University for more than 25 years. He is best known for
significant contributions to the field of transgenic crops, including
the invention of the biolistic process (“gene gun”). Like many in his
profession, he was fully invested in what he terms the “Primary Axiom”
of modern science, namely that “man is merely the product of
random mutations plus
natural selection”
(Sanford, 2008, p. v, italics in orig.). He argues that this
cornerstone of modern Darwinism is almost universally accepted and
rarely, if ever, questioned. In
Genetic Entropy and the Mystery of the Genome,
Sanford proceeds, not only to question the Primary Axiom, but to expose
completely the faulty genetic framework upon which the ideology is
built.
In the first portion of the book, Sanford builds an analogy for the
reader to make complex genetic concepts more palatable to
non-scientists. He uses the analogy of comparing our genome—the sum
total of all of our genetic makeup—with an instruction manual. The DNA
sequences that make up our genes, gene regulatory elements, chromosomes,
etc., are compared with letters, words, chapters, and volumes. [NOTE:
The term “gene” is not to be taken as synonymous with “trait.” Mendelian
genetics dealt in “traits” (e.g., blue eyes) that were defined as
“genes.” Our modern understanding of genetics demonstrates that while
many genes impact phenotype (observable traits), genes are not the same
as traits.] He builds on this analogy throughout the book using several
powerful illustrations.
When we view the genome as an instruction manual, it is not hard to
imagine how instructions in that manual may change simply by randomly
changing letters in the manual. These changes are analogous to the
random changes in our genome that are referred to as
mutations.
Mutations can be as simple as a single “letter” (i.e., a nucleotide)
being changed or as major as the loss or duplication of an entire “book”
(i.e., a chromosome). Our genome includes six billion “letters” split
into 46 “volumes” (in a typical body cell; 23 chromosomes in
reproductive cells). It is clear, though, that randomly changing letters
in an instruction manual would not provide new and useful information.
Sanford argues that, based upon modern scientific evidence and the
calculations of population geneticists (who are almost exclusively
evolutionists), mutations are occurring at an alarmingly high rate in
our genome and that the vast majority of all mutations are either
harmful or “nearly-neutral” (meaning a loss for the organism or having
no discernible fitness gain). Importantly, Sanford also establishes the
extreme rarity of any type of beneficial mutations in comparison with
harmful or “nearly-neutral” mutations. Indeed, “beneficial” mutations
are so exceedingly rare as to not contribute in any meaningful
way. [NOTE: “Beneficial” mutations do not necessarily result from a gain
in information, but instead, these changes predominantly involve a net
loss of function to the organism, which is also not helpful to the
Primary Axiom; see Behe, 2010, pp. 419-445.] Sanford concludes that the
frequency and generally harmful or neutral nature of mutations prevents
them from being useful to any scheme of random evolution.
Using his analogy, imagine a manual for assembling a child’s wagon.
Would randomly changing letters in the manual improve the manual? Would
duplicating sections of the manual improve it? Clearly these types of
changes would destroy information rather than create new information
(having two copies of the same information is not necessarily of
benefit, since there is no real mechanism to preserve one copy while
mutating another). But Sanford extends the analogy further. He suggests
that the Primary Axiom assumes that such random changes not only could
change the wagon, but these random “mutations” would evolve the wagon
into a car and eventually a plane, and then even a space shuttle. No one
would argue that random changes in the manual for a wagon would
eventually give rise to instructions for a space shuttle. However,
Sanford argues this is exactly the situation with regard to our genome.
If we regard “early” life forms in an evolutionary context as being the
wagon, humans would easily be a space shuttle by comparison!
In the next section of the book, Sanford examines natural selection and
asks whether “nature” can “select” in favor of the exceedingly rare
“beneficial” mutations and against the deleterious mutations. The
concept of natural selection is generally that the organisms that are
best adapted to their environment will survive and reproduce, while the
less fit will not. Sanford points out that this may be the case with
some organisms, but more commonly, selection involves chance and luck.
But could this process select against harmful mutations and allow less
harmful or even beneficial mutations to thrive? According to Sanford,
there are significant challenges to this notion. One major issue is the
cost of selection. The cost of selection means that a portion of a
population must be “spent” (i.e., removed) in order to “pay” for the
selection process. To put this idea in human terms, what percentage of
the population could be removed (or kept from reproducing) in order to
promote selection? The numbers are exceedingly high according to
Sanford—possibly higher than 50%—which would be completely unrealistic
in any society today. Another issue is the “blind” nature of the
process. Nature cannot “see” what potential future organisms could
exist, and therefore, there is no means for selecting for or against
traits to achieve any future goals. Sanford concludes that selection
cannot overcome the accumulation of harmful mutations and has no real
power to keep “beneficial” mutations around, due to the extreme rarity
of those mutations and the fact that selection is blind. Thus, even with
the ability to select—artificially or otherwise—the accumulation of
mutations continues unabated.
In the final section of the book, Sanford illustrates the dire
situation of the human genome. Imagine an instruction manual of tens of
thousands of pages in which random changes have been made every time it
is copied. Who would trust such a manual? How many changes would it take
to make the manual unusable? How long before the manual no longer makes
a functional product? It is a testimony to the nature of our genome
that we are still alive in spite of the level of decay. Again, Sanford
points to the accumulation of deleterious mutations and argues that our
genomes are not evolving to something greater; we are decaying and
degenerating. In other words, our genomes at one point were in far
better shape than they are at present. The decay process has taken a
huge toll. This process he terms “genetic entropy.” He suggests that
this decay trend is not only real, but it is an inevitable result of the
random, natural accumulation of mutations in our genome. Thus, not only
do mutations lead to decay, they do not lead to any meaningful increase
in information—which is absolutely required by the Primary Axiom. In
order for organisms to evolve from one form to another, new genetic
information is needed in order to provide “instructions” for building
the proteins and other features of the organism. Sanford clearly
establishes that any expectation of getting new, useful information from
these random processes is a completely blind trust in an impotent
process. His book also provides an appendix with several more arguments
against the Primary Axiom, along with answers to some counterarguments.
In conclusion, Sanford’s book builds a strong case against the Primary
Axiom using modern scientific information combined with powerful, yet
simple, logic. His arguments are solid but written on a level that can
be understood by students and non-scientists. He clarifies several
misconceptions about mutations, natural selection, and the overall decay
of the genome. He accurately describes the concept and reality of
genetic entropy, and he concludes from that principle our dependence
upon the One who designed everything. Rather than viewing life as a
purposeless by-product of the Primary Axiom, Sanford argues that genetic
entropy points us to our need for and reliance upon God as the Creator.
Perhaps this system of genetic decay is simply one more way God reminds
us of the Fall (Genesis 3) and of our complete dependence upon Him.
REFERENCES
Behe, M. J. (2010), “Experimental Evolution, Loss-of-Function Mutations, and ‘the First Rule of Adaptive Evolution,’”
Quarterly Review of Biology, 85[4]:419-445.
Sanford, J.C. (2008),
Genetic Entropy & the Mystery of the Genome (Waterloo, NY: FMS Publications).